PDE8B-IN-1 (hydrochloride)

• UNSPSC Description:

  PDE8B-IN-1 hydrochloride (compound 42) is a potent, selective PDE8B inhibitor with a IC50 value of 1.5 nM. PDE8B-IN-1 hydrochloride can be used in the study of diabetes[1].

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pde8b-in-1-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC(N)=C2N=NN(C[C@H]3CN(CC4=NC=CS4)CCO3)C2=N1.Cl

• Molecular Weight:

  382.87

• References & Citations:

  [1]DeNinno MP, et al. Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5721-6.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1305116-67-9