PDE8B-IN-1 (hydrochloride)

PDE8B-IN-1 (hydrochloride)

• CAS Number: 1305116-67-9
• UNSPSC Description: PDE8B-IN-1 hydrochloride (compound 42) is a potent, selective PDE8B inhibitor with a IC50 value of 1.5 nM. PDE8B-IN-1 hydrochloride can be used in the study of diabetes[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/pde8b-in-1-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=NC(N)=C2N=NN(C[C@H]3CN(CC4=NC=CS4)CCO3)C2=N1.Cl
• Molecular Weight: 382.87
• References & Citations: [1]DeNinno MP, et al. Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5721-6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported