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LSP4-2022

CAT: 0804-HY-117764Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117764Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC50 of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity[1][2].
CAS Number
1413405-33-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lsp4-2022.html
Solubility
10 mM in DMSO
Smiles
OC([C@@H](N)CCP(C(C1=CC=C(C=C1)OCC(O)=O)O)(O)=O)=O
Molecular Formula
C13H18NO8P
Molecular Weight
347.26
References & Citations
[1]Goudet C, et al. A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26 (4) :1682-93.|[2]Podkowa K, Rzeźniczek S, Marciniak M, Acher F, Pilc A, Pałucha-Poniewiera A. A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action. Neuropharmacology. 2015 Oct;97:338-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR7; mGluR8

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