TNKS-IN-2

TNKS-IN-2

• CAS Number: 1584646-59-2
• UNSPSC Description: TNKS-IN-2 (compound 40) is a potent and selective tankyrase (TNKS) inhibitor with pIC50 values of 8.1, 7.0 for TANKS and Wnt, respectively[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tnks-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CCN(CC1)C(C2=CC=C(C=C2)NC3=NC4=C(C=CC=C4)N5C3=NN=N5)=O)C6=NN(C=C6)C
• Molecular Weight: 482.50
• References & Citations: [1]Thomson DW, et al. Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. J Med Chem. 2017 Jul 13;60(13):5455-5471.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported