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TNKS-IN-2

CAT: 0804-HY-117700Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117700Size:1 Each
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Description
TNKS-IN-2 (compound 40) is a potent and selective tankyrase (TNKS) inhibitor with pIC50 values of 8.1, 7.0 for TANKS and Wnt, respectively[1].
CAS Number
1584646-59-2
UNSPSC
12352005
Target
PARP; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnks-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC1)C(C2=CC=C(C=C2)NC3=NC4=C(C=CC=C4)N5C3=NN=N5)=O)C6=NN(C=C6)C
Molecular Formula
C24H22N10O2
Molecular Weight
482.50
References & Citations
[1]Thomson DW, et al. Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. J Med Chem. 2017 Jul 13;60 (13) :5455-5471.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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