Products for Research Use Only
RegisterLogin

TNKS-IN-3

CAT: 0804-HY-173480Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-173480Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TNKS-IN-3 (Compound 6) is a TNKS2 inhibitor (Ki: 8.5 nM) . TNKS-IN-3 has good activity (IC50: 71 nM) and can effectively inhibit the WNT/β-catenin signaling pathway. TNKS-IN-3 can be used in the research of diseases such as cancer and fibrosis[1].
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC=C1OC)C2=CC=C(NC(N(CCC(N3)=NC4=C(C=CC=C4)C3=O)CC5=CC=CS5)=O)C=C2
Molecular Formula
C30H27N5O4S
Molecular Weight
553.63
References & Citations
[1]Sowa ST, et al. Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization. J Med Chem. 2025 Apr 10;68 (7) :7263-7279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS2/PARP5B

Related Products

CatalogName
HY-172747TNKS-2-IN-3
HY-12602TNKS-IN-4
HY-117700TNKS-IN-2
HY-12601TNKS 22
HY-23338-01TNKS-2-IN-1
HY-156332-01TNKS-2-IN-2
HY-RS14840Tnks Mouse Pre-designed siRNA Set A
HY-RS14839TNKS Human Pre-designed siRNA Set A
HY-RS14841Tnks Rat Pre-designed siRNA Set A
HY-W081226-013,3,3-Trifluoropropionyl chloride

Alternative Products

CatalogName
T207469-01TNKS-IN-3
GTR19263940-01TNKS-2-IN-3
579616-01TNKS
BZ65989PCMV6-TNKS-3*FLAG
70R-3098TNKS antibody
T89303-01TNKS 22
579619-01TNKS (HRP)
579617-01TNKS (Biotin)
MBS5774631TNKS-IN-41
GTR19196305-01TNKS-IN-1

Popular Products