Methoxyfenozide-d9

Methoxyfenozide-d9

• CAS Number: 2469014-53-5
• UNSPSC Description: Methoxyfenozide-d9 is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].
• Target Antigen: Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Others
• Field of Research: Others
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C(OC)=CC=C1)C)NN(C(C)(C)C)C(C2=C([2H])C(C([2H])([2H])[2H])=C([2H])C(C([2H])([2H])[2H])=C2[2H])=O
• Molecular Weight: 377.52
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Trisyono, A., et al. Effect of the nonsteroidal ecdysone agonists, methoxyfenozide and tebufenozide, on the European corn borer (Lepidoptera: Pyralidae). J. Econ. Entomol. 90(6), 1486-1492 (1997).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported