TMB-8

CAT: 0804-HY-117099-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-117099-02Size:10 mg

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Description

TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.

CAS Number

53464-72-5

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tmb-8.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C(OC)=CC(C(OCCCCCCCCN(CC)CC)=O)=C1)OC.Cl

Molecular Formula

C22H38ClNO5

Molecular Weight

431.99

References & Citations

[1]Malagodi MH, et al. Pharmacological evaluation of a new Ca2+ antagonist, 8- (N, N-diethylamino) -octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) : studies in smooth muscles. Eur J Pharmacol. 1974 Jun;27 (1) :25-33.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

8-(Diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride

CAS Number	53464-72-5
PubChem CID	6917843
IUPAC Name	8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride
Molecular Formula	C22H38ClNO5
Molecular Weight	432.0
Topological Polar Surface Area	57.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	16
Heavy Atom Count	29
Formal Charge	0
Complexity	388

SMILES

CCN(CC)CCCCCCCCOC(=O)C1=CC(=C(C(=C1)OC)OC)OC.Cl

InChI

InChI=1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H

InChIKey

KFJZVXKPPQIYCG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 53464-72-5

CID: 6917843

Formula: C22H38ClNO5

MW: 432.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	432.0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	16
Exact Mass	431.2438510
Monoisotopic Mass	431.2438510
Topological Polar Surface Area	57.2 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	388
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Catalog	Name
HY-15930-01	TMB
HY-15930A-01	TMB (dihydrochloride)
HY-15930C-01	TMB (monosulfate)
HY-15930R-01	TMB (Standard)
HY-15931-01	TMB-PS
HY-W013758-01	TMB-PS (sodium)
HY-W312068	TMB (dihydrochloride hydrate)
HY-15930B-01	TMB (dihydrochloride x.hydrate)
HY-N8842-01	8,8''-Bibaicalein
HY-160589	Nav1.8-IN-8

Alternative Products

Catalog	Name
T36554-01	TMB 8 (hydrochloride)
sc-3522	TMB-8 • HCl
abx282175-01	TMB-8 HCl
GTR19155450	TMB
64407	TMB Solution A (1% TMB in DMSO)
TBI1209-10MG	TMB-8 HCl, Inhibits intracellular Ca2+ mobilization
C7061-500	TMB dihydrochloride
85R-118	TMB Substrate
85R-119	TMB Weakener
42R-TB103-01	TMB for Histochemistry

TMB-8

Chemical Information

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