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12,13-DiHOME

CAT: 0804-HY-116003Size: 500 μg (318.01 μM x 5 mL in Methyl acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-116003Size:500 μg (318.01 μM x 5 mL in Methyl acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±) 12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±) 12,13-DiHOME can be used for research of metabolic disorders[1].
CAS Number
263399-35-5
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/12-13-dihome.html
Concentration
318.01 μM * 5 mL in Methyl acetate
Purity
99.5
Solubility
10 mM in DMSO
Smiles
CCCCCC(C(C/C=C\CCCCCCCC(O)=O)O)O
Molecular Formula
C18H34O4
Molecular Weight
314.46
Precautions
H225, H319, H336
References & Citations
[1]Lynes MD, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23 (5) :631-637.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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