12-Deoxyphorbol 13-palmitate

12-Deoxyphorbol 13-palmitate

• CAS Number: 66583-59-3
• UNSPSC Description: 12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2[1][2].
• Target Antigen: Apoptosis; CDK
• Type: Natural Products
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/12-deoxyphorbol-13-palmitate.html
• Smiles: CCCCCCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
• Molecular Weight: 586.84
• References & Citations: [1]HuiYu Xu, et al. "12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells." European journal of pharmacology 700.1-3 (2013): 13-22.|[2]Lu Gan, et al. "A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2." Nature Chemical Biology (2024): 1-11.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported