GPVI antagonist 3

• Description :

  GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI) . IC50 values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent[1].

• CAS Number :

  [901654-94-2]

• UNSPSC :

  12352005

• Target :

  Glycoprotein VI

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/gpvi-antagonist-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(CCCO)C(C2=CC=C(OC)C=C2)C3=C1NN=C3C4=CC(C)=CC=C4O

• Molecular Formula :

  C22H23N3O4

• Molecular Weight :

  393.44

• References & Citations :

  [1]Olğaç S, et al. Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study. Bioorg Chem. 2022;121:105661.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported