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RTIL 13

CAT: 0804-HY-115739Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115739Size:1 Each
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Description
RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[1][2].
CAS Number
1009376-10-6
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rtil-13.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2([H])[C@](C(N1CC[N+](C)(C)CCCCCCCCCCCCCCCCCC)=O)([H])[C@H]3O[C@@H]2CC3.[Br-]
Molecular Formula
C30H55BrN2O3
Molecular Weight
571.67
References & Citations
[1]Zhang J, et, al. From Spanish fly to room-temperature ionic liquids (RTILs) : synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry. 2008 Jan; 32 (1) : 1-180.|[2]Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle. Tuesday, December 28, 2021.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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