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α-Amylase-IN-13

CAT: 0804-HY-178363Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178363Size:1 Each
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Description
α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC50 = 0.71 μM) . α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications[1].
CAS Number
3085413-64-2
UNSPSC
12352005
Target
Amylases
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C(NC1=CC=C(C(F)(F)F)C=C1)CN(C/2=O)C(SC2=C/C3=NC=CN3C)=S
Molecular Formula
C17H13F3N4O2S2
Molecular Weight
426.44
References & Citations
[1]Ravi A, et al. Synthesis, in vitro and in vivo evaluation, and computational modeling analysis of thioxothiazolidine derivatives as highly potent and selective α-amylase inhibitors. Eur J Med Chem. 2025 Jul 5;291:117584.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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