TIQ-15

• Description:

  TIQ-15 is a potent CXCR4 antagonist with an IC50 value of 6 nM for CXCR4 Ca2+ flux. TIQ-15 inhibits CYP450 2D6 with an IC50 value of 0.32 μM[1].

• UNSPSC:

  12352005

• Target:

  CXCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/tiq-15.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCCN (C[C@@H]1NCC2=C (C=CC=C2) C1) [C@H]3CCCC4=C3N=CC=C4

• Molecular Formula:

  C23H32N4

• Molecular Weight:

  364.53

• References & Citations:

  [1]Tahirovic YA, et, al. Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties. ACS Med Chem Lett. 2018 Apr 9;9 (5) :446-451.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CXCR4

• CAS Number:

  1380336-17-3