PF-00356231

CAT: 0804-HY-114091ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-114091ASize:1 Each
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Description
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM) . PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].
CAS Number
[766536-21-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-00356231.html
Solubility
10 mM in DMSO
Smiles
OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O
Molecular Formula
C25H20N2O3S
Molecular Weight
428.50
Precautions
P261-P280-P302+P352
References & Citations
[1]Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341 (4) :1063-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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