J-113397

• Description :

  J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist (Ki: cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors[1].

• CAS Number :

  [256640-45-6]

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/j-113397.html

• Purity :

  99.00

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming)

• Smiles :

  O=C1N([C@H]2[C@@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC

• Molecular Formula :

  C24H37N3O2

• Molecular Weight :

  399.57

• References & Citations :

  [1]Ozaki S, et al. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur J Pharmacol. 2000 Aug 18;402 (1-2) :45-53.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NOP Receptor/ORL1; δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR