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J-113397

CAT: 0804-HY-114072-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114072-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist (Ki: cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors[1].
CAS Number
256640-45-6
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/j-113397.html
Purity
99.00
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C1N([C@H]2[C@@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC
Molecular Formula
C24H37N3O2
Molecular Weight
399.57
References & Citations
[1]Ozaki S, et al. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur J Pharmacol. 2000 Aug 18;402 (1-2) :45-53.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1; δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

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