4-Hydroxynonenal-d3

• Description :

  4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

• CAS Number :

  [148706-06-3]

• Product Name Alternative :

  4-HNE-d3

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Concentration :

  3.14 mM * 100 μL in Methyl acetate

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C/C=C/C(O)CCCCC([2H])([2H])[2H]

• Molecular Formula :

  C9H13D3O2

• Molecular Weight :

  159.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[3]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[4]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, protect from light, 2 years

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  ALDH2