4-Hydroxynonenal (Standard)

• Description :

  4-Hydroxynonenal (Standard) is the analytical standard of 4-Hydroxynonenal. This product is intended for research and analytical applications. 4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

• CAS Number :

  [75899-68-2]

• UNSPSC :

  12352100

• Target :

  Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite; Reference Standards

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Smiles :

  CCCCCC(O)/C=C/C=O

• Molecular Formula :

  C9H16O2

• Molecular Weight :

  156.22

• References & Citations :

  [1]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[2]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[3]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards