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4-Hydroxynonenal

CAT: 0804-HY-113466-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113466-01Size:5 mg
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Description
4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
CAS Number
75899-68-2
Product Name Alternative
4-HNE
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxynonenal.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCC(O)/C=C/C=O
Molecular Formula
C9H16O2
Molecular Weight
156.22
Precautions
H225, H319
References & Citations
[1]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[2]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[3]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH2; Human Endogenous Metabolite

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