4-Hydroxynonenal

• Description :

  4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

• Product Name Alternative :

  4-HNE

• UNSPSC :

  12352211

• Hazard Statement :

  H225, H319

• Target :

  Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxynonenal.html

• Purity :

  99.35

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCCC(O)/C=C/C=O

• Molecular Formula :

  C9H16O2

• Molecular Weight :

  156.22

• Precautions :

  H225, H319

• References & Citations :

  [1]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[2]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[3]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALDH2; Human Endogenous Metabolite

• CAS Number :

  [75899-68-2]