Guanosine 5'-diphosphate-d13 (dilithium)

Guanosine 5'-diphosphate-d13 (dilithium)

• UNSPSC Description: Guanosine 5'-diphosphate-d13 (GDP-d13) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Solubility: 10 mM in DMSO
• Smiles: O=P(OP(OC([2H])([2H])[C@]1([2H])[C@]([2H])(O[2H])[C@@]([2H])(O[2H])[C@@](N2C([2H])=NC3=C2N=C(N([2H])[2H])N([2H])C3=O)([2H])O1)(O[2H])=O)(O[Li])O[Li]
• Molecular Weight: 468.15
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.|[3]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported