Guanosine 5'-diphosphate-13C10 (dilithium)
CAT:
804-HY-113066S1
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Guanosine 5'-diphosphate-13C10 (dilithium)
- UNSPSC Description: Guanosine 5'-diphosphate-13C10 (GDP-13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
- Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel
- Type: Isotope-Labeled Compounds
- Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/guanosine-5-diphosphate-13c10-dilithium.html
- Solubility: 10 mM in DMSO
- Smiles: O=P(OP(O[Li])(O[Li])=O)(O)O[13CH][13C@@H]1[13C@@](O)[13C@@](O)[13C@H](N2[13C](N=[13C](N)N[13C]3=O)=[13C]3N=[13CH]2)O1
- Molecular Weight: 461.97
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.|[3]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported