N1-Methylpseudouridine-5′-triphosphate

N1-Methylpseudouridine-5′-triphosphate

• CAS Number: 1428903-59-6
• UNSPSC Description: N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
• Target Antigen: DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/n1-methylpseudouridine-5-triphosphate.html
• Purity: 99.4
• Solubility: 10 mM in H2O
• Smiles: O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
• Molecular Weight: 498.17
• References & Citations: [1]Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported