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RGB-286147

CAT: 0804-HY-112346Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112346Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity[1].
CAS Number
784211-09-2
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rgb-286147.html
Purity
98.60
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(N(C3=C(Cl)C=CC=C3Cl)N=C2C(C)C)N=C(CC4=CC=C(OCCO)C=C4)N1
Molecular Formula
C23H22Cl2N4O3
Molecular Weight
473.35
References & Citations
[1]Maureen Caligiuri, et al. A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol. 2005 Oct;12 (10) :1103-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK6

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