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RGB-286638

CAT: 0804-HY-15504-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15504-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
CAS Number
784210-87-3
UNSPSC
12352005
Target
CDK; GSK-3; JAK; MEK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RGB-286638.html
Purity
99.70
Solubility
DMSO : ≥ 150 mg/mL|H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(NN1CCOCC1)NC2=CC=CC(C3=C4C(C5=CC=C(CN6CCN(CCOC)CC6)C=C5)=NN3)=C2C4=O.[H]Cl.[H]Cl
Molecular Formula
C29H37Cl2N7O4
Molecular Weight
618.55
References & Citations
[1]Cirstea D, et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27 (12) :2366-75.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9; GSK-3β; JAK2; MEK1
Citation 01
University of Washington. 2025.|Cancers (Basel) . 2022 Mar 19;14 (6) :1575.|Science. 2017 Dec 1;358 (6367) :eaan4368.

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