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Fascaplysin

CAT: 0804-HY-112328Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112328Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.) . Fascaplysin has been synthesized in seven steps from indole (65% yield) . Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].
CAS Number
114719-57-2
UNSPSC
12352005
Target
Apoptosis; Autophagy; CDK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/fascaplysin.html
Purity
95.6
Solubility
10 mM in DMSO
Smiles
O=C1C2=C3NC4=C(C=CC=C4)C3=CC=[N+]2C5=C1C=CC=C5.[Cl-]
Molecular Formula
C18H11ClN2O
Molecular Weight
306.75
References & Citations
[1]BenjaminPelcman, Gordon WGribble. Total synthesis of the marine sponge pigment fascaplysin. Tetrahedron Letters. 1990, 31 (17) :2381-2384.|[2]Zhidkov ME, et al. Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues. Mar Drugs. 2019 Aug 25;17 (9) :496.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CDK4

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