Narasin (sodium)

• Description:

  Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Antibiotic; Apoptosis; Bacterial; NF-κB; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/narasin-sodium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@]2 (O[C@] (C) ([C@]3 ([H]) O[C@H] ([C@] (CC) (O) CC3) C) CC2) O[C@@]4 (O[C@] ([C@@H] (C) C[C@H]4C) ([H]) [C@@H] (CC) C ([C@@H] (C) [C@@H] (O) [C@@H] ([C@]5 ([H]) O[C@@] ([C@@H] (C) C[C@@H]5C) ([H]) [C@@H] (CC) C (O[Na]) =O) C) =O) C=C1

• Molecular Formula:

  C43H71NaO11

• Molecular Weight:

  787.01

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Miller SC, et al. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol. 2010 May 1;79 (9) :1272-80.|[2]Ghada Bouguerra, et al. Stimulation of Eryptosis by Narasin. Cell Physiol Biochem. 2015;37 (5) :1807-16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  58331-17-2