Products for Research Use Only
RegisterLogin

EG01377

CAT: 0804-HY-112151-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112151-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects[1].
CAS Number
2227996-00-9
UNSPSC
12352005
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EG01377.html
Purity
99.90
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O
Molecular Formula
C26H30N6O6S2
Molecular Weight
586.68
References & Citations
[1]Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61 (9) :4135-4154.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cancers (Basel) . 2023 Apr 10;15 (8) :2225.|Cell Death Dis. 2023 Feb 25;14 (2) :159.|J Virol. 2025 Oct 29:e0138425.

Chemical Information

(3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine
CAS Number2227996-00-9
PubChem CID133081972
IUPAC Name(2S)-2-[[3-[[5-[4-(aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl]sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular FormulaC26H30N6O6S2
Molecular Weight586.7
XLogP-0.7
Topological Polar Surface Area249
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count12
Heavy Atom Count40
Formal Charge0
Complexity1010
SMILES
C1COC2=C1C=C(C=C2S(=O)(=O)NC3=C(SC=C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C4=CC=C(C=C4)CN
InChI
InChI=1S/C26H30N6O6S2/c27-14-15-3-5-16(6-4-15)18-12-17-7-10-38-22(17)21(13-18)40(36,37)32-19-8-11-39-23(19)24(33)31-20(25(34)35)2-1-9-30-26(28)29/h3-6,8,11-13,20,32H,1-2,7,9-10,14,27H2,(H,31,33)(H,34,35)(H4,28,29,30)/t20-/m0/s1
InChIKey
SEXUXSMBJLNXIR-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of (3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine
CAS: 2227996-00-9
CID: 133081972
Formula: C26H30N6O6S2
MW: 586.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight586.7
XLogP3-0.7
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count12
Exact Mass586.16682505
Monoisotopic Mass586.16682505
Topological Polar Surface Area249 Ų
Heavy Atom Count40
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5766567EG01377
MBS5814721EG01377 dihydrochloride
BUP12834-01EG01377 2HCl
MBS3842152-01EG01377 TFA
A17177-50EG01377 TFA 50mg
A24483-10EG01377 dihydrochloride 10mg
A24483-5EG01377 dihydrochloride 5mg
A24483-1EG01377 dihydrochloride 1mg
A17177-5EG01377 TFA 5mg
A24483-50EG01377 dihydrochloride 50mg

Popular Products