EG01377

• Description :

  EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects[1].

• UNSPSC :

  12352005

• Target :

  Complement System

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/EG01377.html

• Purity :

  99.90

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O

• Molecular Formula :

  C26H30N6O6S2

• Molecular Weight :

  586.68

• References & Citations :

  [1]Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61 (9) :4135-4154.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Cancers (Basel) . 2023 Apr 10;15 (8) :2225.|Cell Death Dis. 2023 Feb 25;14 (2) :159.|J Virol. 2025 Oct 29:e0138425.

• CAS Number :

  [2227996-00-9]