EG01377

• Description:

  EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects[1].

• UNSPSC:

  12352005

• Target:

  Complement System

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/EG01377.html

• Purity:

  99.90

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O

• Molecular Formula:

  C26H30N6O6S2

• Molecular Weight:

  586.68

• References & Citations:

  [1]Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61 (9) :4135-4154.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Cancers (Basel) . 2023 Apr 10;15 (8) :2225.|Cell Death Dis. 2023 Feb 25;14 (2) :159.|J Virol. 2025 Oct 29:e0138425.

• CAS Number:

  [2227996-00-9]