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GSK8175

CAT: 0804-HY-112047Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-112047Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV) . GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons[1].
CAS Number
[1423007-82-2]
Product Name Alternative
GSK2878175
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gsk8175.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C(C=C2)=CC=C2F)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)[S](C)(=O)=O)=C(C6CC6)C=C13)NC
Molecular Formula
C27H23BClFN2O6S
Molecular Weight
568.81
References & Citations
[1]Chong PY, et al. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J Med Chem. 2019;62 (7) :3254-3267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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