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AmPEG6C2-Aur0131

CAT: 0804-HY-111555Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111555Size:1 Each
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Description
AmPEG6C2-Aur0131 is a agent-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0131 (an auristatin microtubule inhibitor), linked via the non-cleavable linker AmPEG6C2[1].
CAS Number
1650569-94-0
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AmPEG6C2-Aur0131.html
Solubility
10 mM in DMSO
Smiles
NCCOCCOCCOCCOCCOCCOCCC(N1[C@@](C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@H]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)CCC2)=O)=O)=O)(C)CCC1)=O
Molecular Formula
C54H92N6O15
Molecular Weight
1065.34
References & Citations
[1]Costa MJ, et al. Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates. Sci Rep. 2019 Feb 21;9 (1) :2443.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

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