RegisterLogin

TAK-828F

CAT: 0804-HY-111509Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111509Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM) . TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ) [1].
CAS Number
[1854901-94-2]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TAK-828F.html
Solubility
10 mM in DMSO
Smiles
CC1(C)C2=C(F)C=C(NC([C@@H]3N(C([C@@H]4C[C@H](CC(O)=O)C4)=O)CCC5=C3C=CC(OC)=N5)=O)C=C2CC1
Molecular Formula
C28H32FN3O5
Molecular Weight
509.57
References & Citations
[1]Kono M, et al. Discovery of [ cis-3- ({ (5 R) -5-[ (7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl) carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6 (5 H) -yl}carbonyl) cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist. J Med Chem. 2018 Apr 12;61 (7) :2973-2988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-100254TAK-024
HY-105534TAK-637
HY-15196-01TAK-285
HY-169949TAK-756
HY-171446TAK-075
HY-103493-01TAK-915
HY-19974-01TAK-220
HY-P0076-01TAK-448
HY-132879-01TAK-020
HY-16475-01TAK-441

Alternative Products

CatalogName
MBS5767691TAK-828F
A19611-50TAK-828F 50mg
A19611-100TAK-828F 100mg
A19611-5TAK-828F 5mg
A19611-25TAK-828F 25mg
A19611-1TAK-828F 1mg
A19611-10TAK-828F 10mg
MBS3600006-01TAK-875
MBS3617353-01TAK-615
MBS3617130-01TAK-041

Popular Products