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Naphazoline

CAT: 0804-HY-111326-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111326-02Size:10 mg
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Description
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research[1][2].
CAS Number
835-31-4
Product Name Alternative
Naphthazoline
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/naphazoline.html
Purity
99.74
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1
Molecular Formula
C14H14N2
Molecular Weight
210.27
Precautions
H315, H319, H320
References & Citations
[1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13 (4) :3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203 (1) :125-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IL-1; IL-4; IL-6; TNFRSF5/CD40

Chemical Information

Naphazoline

2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

CAS Number835-31-4
PubChem CID4436
IUPAC Name2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Molecular FormulaC14H14N2
Molecular Weight210.27
XLogP2.1
Topological Polar Surface Area24.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count16
Formal Charge0
Complexity272
SMILES
C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
InChI
InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
InChIKey
CNIIGCLFLJGOGP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Naphazoline
CAS: 835-31-4
CID: 4436
Formula: C14H14N2
MW: 210.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight210.27
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass210.115698455
Monoisotopic Mass210.115698455
Topological Polar Surface Area24.4 Ų
Heavy Atom Count16
Formal Charge0
Complexity272
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP06580-01Naphazoline
B1340-10000Naphazoline HCl
540309Naphazoline nitrate
N7870-01Naphazoline hydrochloride
E4825-100mgNaphazoline (nitrate)

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