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M084 (hydrochloride)

CAT: 0804-HY-110379Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-110379Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M084 hydrochloride is a TRPC4/5 channel blocker, with IC50 values of 10.3 μM and 8.2 μM, respectively. M084 hydrochloride has antidepressant and anxiolytic effects[1][2].
CAS Number
1992047-63-8
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/m084-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCCCNC1=NC2=CC=CC=C2N1.Cl
Molecular Formula
C11H16ClN3
Molecular Weight
225.72
References & Citations
[1]Yang LP, et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice. PLoS One. 2015 Aug 28;10 (8) :e0136255.|[2]Zhu Y, et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015 Jul;172 (14) :3495-509.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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