TWS119 (TFA)

• Description :

  TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

• CAS Number :

  [1507095-58-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Others; Wnt

• Type :

  Reference compound

• Related Pathways :

  Others; Stem Cell/Wnt

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/tws119-tfa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

• Molecular Formula :

  C22H16F6N4O6

• Molecular Weight :

  546.38

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104 (36) :14190-6.|[2]Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104 (36) :14190-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported