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APcK110

CAT: 0804-HY-110071Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-110071Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML) . APcK110 induces AML cell apoptosis[1].
CAS Number
1001083-74-4
UNSPSC
12352005
Target
C-Kit
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apck110.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C2=NNC3=NC(C4=CC(OC)=CC(OC)=C4)=CC=C23)C=C1
Molecular Formula
C20H16FN3O2
Molecular Weight
349.36
References & Citations
[1]Faderl S, et al. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Res. 2009 May 1;69 (9) :3910-7.|[2]Faderl S, et al. Kit inhibitor APcK110 extends survival in an AML xenograft mouse model. Invest New Drugs. 2011 Oct;29 (5) :1094-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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