Products for Research Use Only
RegisterLogin

APcK110

CAT: 0931-T71654-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T71654-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1001083-74-4
Target
Others, c-Kit
Related Pathways
Tyrosine Kinase/Adaptors, Others
Bioactivity
APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling pathways . APcK110 may have potent application in AML.
Smiles
FC1=CC=C(C=2C=3C(=NC(=CC3)C4=CC(OC)=CC(OC)=C4)NN2)C=C1
Molecular Formula
C20H16FN3O2
Molecular Weight
349.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1001083-74-4

PubChem
cas1001083-74-4
modify2026-05-17
synonyms
APcK1101001083-74-4APcK 110
6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine
6-(3,5-dimethoxyphenyl)-3-(4-fluorophenyl)-2H-pyrazolo[3,4-b]pyridine
APcK-110orb1737807CHEMBL4303655SCHEMBL11939489SCHEMBL29434984+ 15 more
PubChem LinkClick here

Related Products

CatalogName
TMAB-02732-01Anti-APC10 Polyclonal Antibody

Alternative Products

CatalogName
HY-110071APcK110

Popular Products