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Terreic acid

CAT: 0804-HY-110013Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110013Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].
CAS Number
121-40-4
UNSPSC
12352005
Hazard Statement
H302+H312
Target
Antibiotic; Btk
Type
Reference compound
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/terreic-acid.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2
Molecular Formula
C7H6O4
Molecular Weight
154.12
Precautions
H302+H312
References & Citations
[1]Y Kawakami, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96 (5) :2227-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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