Terreic acid

• Description:

  Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312

• Target:

  Antibiotic; Btk

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/terreic-acid.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@H]2[C@H] (C (C (O) =C1C) =O) O2

• Molecular Formula:

  C7H6O4

• Molecular Weight:

  154.12

• Precautions:

  H302+H312

• References & Citations:

  [1]Y Kawakami, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96 (5) :2227-32.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  121-40-4