Terreic acid

• Description :

  Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312

• Target :

  Antibiotic; Btk

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/terreic-acid.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1[C@@H]2[C@H](C(C(O)=C1C)=O)O2

• Molecular Formula :

  C7H6O4

• Molecular Weight :

  154.12

• Precautions :

  H302+H312

• References & Citations :

  [1]Y Kawakami, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96 (5) :2227-32.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [121-40-4]