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Cedazuridine (hydrochloride)

CAT: 0804-HY-109081ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109081ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research[1].
Product Name Alternative
E7727 (hydrochloride)
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cedazuridine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.FC1([C@H](N(CC[C@@H](O)N2)C2=O)O[C@H](CO)[C@H]1O)F
Molecular Formula
C9H15ClF2N2O5
Molecular Weight
304.68
References & Citations
[1]Ferraris D, et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27; 57 (6) :2582-8.|[2]Ramsey H E, et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Targeted Oncology, 2020, 15 (2) : 231-240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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