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Dornase alfa

CAT: 0804-HY-108858Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-108858Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms[1][2][3][4].
CAS Number
143831-71-4
Product Name Alternative
RhDNase
UNSPSC
12352204
Target
DNA/RNA Synthesis; Endonuclease
Type
Enzyme
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dornase-alfa.html
Purity
0
Solubility
10 mM in DMSO
Smiles
[Dornasealfa]
References & Citations
[1]Connie Yang, et al. Dornase alfa for cystic fibrosis. Cochrane Database Syst Rev. 2021 Mar 18;3 (3) :CD001127.|[2]Konstan MW, et al. Effect of dornase alfa on inflammation and lung function: potential role in the early treatment of cystic fibrosis. J Cyst Fibros. 2012 Mar;11 (2) :78-83.|[3]Chang KH, et al. Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics. 2020 Jul 31;12 (8) :721.|[4]Alekseeva L A, et al. Dornase alfa reduces the number of metastases in the B16 melanoma model and alters the pattern of cfDNA in the blood serum[J]. 2022.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Enzyme
Clinical Information
Phase 4

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