G-418

• UNSPSC Description:

  G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

• Target Antigen:

  Antibiotic; Bacterial; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/g-418.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]([C@@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)N)([H])O[C@]2([H])[C@H](O)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O

• Molecular Weight:

  496.55

• References & Citations:

  [1]S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70.Acta Pharmacol Sin. 2023 May 16.|Cell Mol Biol Lett. 2024 Feb 17;29(1):26.|FASEB J. 2023 Nov;37(11):e23195.|Research Square Preprint. 2023 Jul 11.|SSRN. 2024 Jun 19.|Am J Cancer Res. 2021 May 15;11(5):2062-2080.|Cancer Commun (Lond). 2022 Nov 9.|Cancer Res. 2023 Feb 6;CAN-22-3169.|Cell Death Differ. 2020 Jun;27(6):1981-1997.|Cell Death Dis. 2020 Jun 4;11(6):420.|Cell Death Dis. 2019 May 28;10(6):413.|Cell Rep. 2020 Oct 20;33(3):108287.|Cell Rep. 2021 Mar 30;34(13):108906.|Cell Rep. 2021 Sep 21;36(12):109739.|Cell Rep. 2022 Oct 25;41(4):111561.|Chemosphere. 2024 Sep 24:143350.|Emerg Microbes Infect. 2023 Sep 19;2261556.|Environ Toxicol. 2024 Jul 2.|Hum Cell. 2022 Jul 6.|J Agric Food Chem. 2022 Apr 6;70(13):3989-3999.|J Biol Chem. 2023 Mar 17;104621.|J Cell Mol Med. 2023 Mar 13.|J Genet Genomics. 2021 Mar 30.|Life Sci. 2024 Jun 1:346:122626.|Med Oncol. 2021 Nov 10;39(1):10.|Mol Cell. 2023 Nov 20:S1097-2765(23)00914-0.|Nature. 2023 Jun;618(7966):862-870.|Oxid Med Cell Longev. 2022 Jan 28;2022:8168988.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Nov.|Research Square Print. 2023 Feb 21.|Sci Adv. 2024 Aug 16;10(33):eado1533.|Theranostics. 2022 Jan 1;12(3):1187-1203.|Transl Cancer Res. 2023 Jan 23; 12(1):150-162.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  49863-47-0