Enterolactone-d6

• Description :

  Enterolactone-d6 is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Purity :

  95.0

• Solubility :

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles :

  C([C@H]1[C@H](CC2=C(C(O)=C(C=C2[2H])[2H])[2H])C(=O)OC1)C3=C(C(O)=C(C=C3[2H])[2H])[2H]

• Molecular Formula :

  C18H12D6O4

• Molecular Weight :

  304.37

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.|[3]Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15 (2) :137-156.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [104411-11-2]