Enterolactone-13C3

• Description :

  Enterolactone-13C3 is the 13C-labeled Enterolactone (HY-108692) . Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Smiles :

  OC1=CC=CC([13CH2][C@@H]([13C](OC2)=O)[C@H]2[13CH2]C3=CC(O)=CC=C3)=C1

• Molecular Formula :

  C15 13C3H18O4

• Molecular Weight :

  301.31

• References & Citations :

  [1]Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.|[2]Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15 (2) :137-156.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [918502-72-4]