EO 1428

• Description :

  EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].

• UNSPSC :

  12352005

• Target :

  P38 MAPK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/eo-1428.html

• Purity :

  99.65

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C(NC2=CC=C(Br)C=C2N)C=C1Cl)C3=CC=CC=C3C

• Molecular Formula :

  C20H16BrClN2O

• Molecular Weight :

  415.71

• References & Citations :

  [1]Alasdair J Scott, et al. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011 Oct 14;286 (41) :35466-35476.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [321351-00-2]