EO 1428

• Description:

  EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/eo-1428.html

• Purity:

  99.65

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=C (NC2=CC=C (Br) C=C2N) C=C1Cl) C3=CC=CC=C3C

• Molecular Formula:

  C20H16BrClN2O

• Molecular Weight:

  415.71

• References & Citations:

  [1]Alasdair J Scott, et al. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011 Oct 14;286 (41) :35466-35476.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  321351-00-2