EO 1428

• UNSPSC Description:

  EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].

• Target Antigen:

  p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/eo-1428.html

• Purity:

  98.0

• Solubility:

  DMSO : 41.57 mg/mL (ultrasonic;warming)

• Smiles:

  O=C(C1=CC=C(NC2=CC=C(Br)C=C2N)C=C1Cl)C3=CC=CC=C3C

• Molecular Weight:

  415.71

• References & Citations:

  [1]Alasdair J Scott, et al. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011 Oct 14;286(41):35466-35476.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  321351-00-2