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VU0155069 (hydrochloride)

CAT: 0804-HY-108612ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108612ASize:1 Each
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Description
VU0155069 hydrochloride (CAY10593 hydrochloride) is a potent selective phospholipase D (PLD) inhibitor. The IC50 values for PLD1 and PLD2 are 46 and 933 nM, respectively. VU0155069 hydrochloride inhibits migration of human and mouse breast cancer cell lines[1][2].
CAS Number
1781834-89-6
Product Name Alternative
CAY10593 (hydrochloride)
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vu0155069-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2C=CC=CC2=C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Cl)C=C5NC4=O)CC3.Cl
Molecular Formula
C26H28Cl2N4O2
Molecular Weight
499.43
References & Citations
[1]Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5 (2) :108-17.|[2]Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1916-20.|[3]Barclay Z, et al. Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT (2A) receptor. Cell Signal. 2013 Apr;25 (4) :814-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLD

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Alternative Products

CatalogName
T84879-01VU0155069 hydrochloride
MBS3844385-01VU0155069
A19933-10VU0155069 10mg
A19933-1VU0155069 1mg
A19933-25VU0155069 25mg
A19933-5VU0155069 5mg
C06971CAY10593 (VU0155069)
A19933-100VU0155069 100mg
A19933-50VU0155069 50mg
A19933-2VU0155069 2mg

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