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VU0155069

CAT: 0804-HY-108612-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108612-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0155069 (CAY10593), is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[1][2].
CAS Number
1130067-06-9
Product Name Alternative
CAY10593
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vu0155069.html
Purity
98.55
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=CC=CC2=C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Cl)C=C5NC4=O)CC3
Molecular Formula
C26H27ClN4O2
Molecular Weight
462.97
References & Citations
[1]Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5 (2) :108-17.|[2]Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1916-20.|[3]Barclay Z, et al. Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT (2A) receptor. Cell Signal. 2013 Apr;25 (4) :814-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLD

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