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Bryostatin 3

CAT: 0804-HY-108602Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-108602Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].
CAS Number
143370-84-7
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bryostatin-3.html
Solubility
10 mM in DMSO
Smiles
CCC/C=C/C=C/C(O[C@H]1C([C@@](O2)([H])[C@]3([H])O[C@]1(C(C)(/C=C\[C@](C/4)([H])O[C@](CC4=C\C(OC)=O)([H])C[C@@](C(C)([C@@H](OC(C)=O)C[C@@]5([H])C[C@@H](O)CC(OC([C@H](O)C)C3)=O)C)(O5)O)C)O)=CC2=O)=O
Molecular Formula
C46H64O17
Molecular Weight
888.99
References & Citations
[1]Wender PA, et, al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A. 1988 Oct;85 (19) :7197-201.|[2]Mackanos EA, et, al. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J Biol Chem. 1991 Jun 15;266 (17) :11205-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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