SIB-1508Y

CAT: 0804-HY-107681Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107681Size:1 Each
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Description
SIB-1508Y is an orally active and selective nAChR agonist. SIB-1508Y has the potential to study parkinsonism[1][2]. SIB-1508Y is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[192231-16-6]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sib-1508y.html
Solubility
10 mM in DMSO
Smiles
CN1[C@H](C2=CN=CC(C#C)=C2)CCC1.OC(/C=C\C(O)=O)=O
Molecular Formula
C16H18N2O4
Molecular Weight
302.33
References & Citations
[1]Cosford ND, et al. (S) - (-) -5-ethynyl-3- (1-methyl-2-pyrrolidinyl) pyridine maleate (SIB-1508Y) : a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem. 1996 Aug 16;39 (17) :3235-7.|[2]Schneider JS, et al. Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys. Mov Disord. 1998 Jul;13 (4) :637-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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