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Cryptophycin analog 1

CAT: 0804-HY-107502Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107502Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cryptophycin analog 1 is an ADC payload. Cryptophycin analog 1 shows anticancer activity. Cryptophycin analog 1 displays cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1[1].
CAS Number
[1260431-28-4]
UNSPSC
12352005
Target
Antibody-Drug Conjugates (ADCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cryptophycin-analog-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(C)(C)C(O[C@H](C(O1)=O)CC(C)C)=O)[C@@H](CC2=CC=C(OC)C(Cl)=C2)NC(/C=C/C[C@H]1[C@H](C)[C@@H]3[C@H](O3)C4=CC=C(CN)C=C4)=O
Molecular Formula
C37H48ClN3O8
Molecular Weight
698.25
References & Citations
[1]Verma VA, et al. The cryptophycins as potent payloads for antibody drug conjugates. Bioorg Med Chem Lett. 2015 Feb 15;25 (4) :864-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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