Cryptophycin analog 1

• Description:

  Cryptophycin analog 1 is an ADC payload. Cryptophycin analog 1 shows anticancer activity. Cryptophycin analog 1 displays cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1[1].

• UNSPSC:

  12352005

• Target:

  Antibody-Drug Conjugates (ADCs)

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cryptophycin-analog-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC(C)(C)C(O[C@H](C(O1)=O)CC(C)C)=O)[C@@H](CC2=CC=C(OC)C(Cl)=C2)NC(/C=C/C[C@H]1[C@H](C)[C@@H]3[C@H](O3)C4=CC=C(CN)C=C4)=O

• Molecular Formula:

  C37H48ClN3O8

• Molecular Weight:

  698.25

• References & Citations:

  [1]Verma VA, et al. The cryptophycins as potent payloads for antibody drug conjugates. Bioorg Med Chem Lett. 2015 Feb 15;25 (4) :864-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1260431-28-4]