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Amtolmetin guacil

CAT: 0804-HY-107320-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107320-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX) . Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO) . Amtolmetin guacil can be used to research knee osteoarthritis[1][2].
CAS Number
87344-06-7
UNSPSC
12352005
Hazard Statement
H301
Target
COX; NO Synthase; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amtolmetin-guacil.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C)C=C1)C2=CC=C(CC(NCC(OC3=C(C=CC=C3)OC)=O)=O)N2C
Molecular Formula
C24H24N2O5
Molecular Weight
420.46
Precautions
H301
References & Citations
[1]Marcolongo, R., et al. A Meta-Analysis of the Tolerability of Amtolmetin Guacil, a Novel, Effective Nonsteroidal Anti-Inflammatory Drug, Compared with Established Agents. Clin. Drug Investig. 17, 89-96 (1999) .|[2]Niccoli L, et al. Renal tolerability of three commonly employed non-steroidal anti-inflammatory drugs in elderly patients with osteoarthritis. Clin Exp Rheumatol. 2002 Mar-Apr;20 (2) :201-7.|[3]Hotha KK, et al. Species difference in the in vitro and in vivo metabolism of amtolmetin guacil. Arzneimittelforschung. 2010;60 (11) :667-74.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched

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