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Guaiol

CAT: 0804-HY-N3980-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3980-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[1][2][3][4][5][6].
CAS Number
489-86-1
Product Name Alternative
Champacol; Guaiac alcohol
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; RAD51
Type
Natural Products
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/guaiol.html
Purity
99.67
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C[C@@H]1C2=C([C@H](CC[C@@H](C(C)(O)C)C2)C)CC1
Molecular Formula
C15H26O
Molecular Weight
222.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang, Q, et al. (−) -Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Oncotarget. 2016 Sep 20;7 (38) :62585-62597.|[2]Ali, A., Tabanca, et al. Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes J. Agric. Food Chem. 63 (2), 447-456 (2015) .|[3]Liu, T, et al. Guaiol - a naturally occurring insecticidal sesquiterpene Nat. Prod. Commun. 8 (10), 1353-1354 (2013) .|[4]Garcia M C F, et al. The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against Leishmania amazonensis[J]. Parasitology, 2018, 145 (9) : 1219-1227.|[5]Thurman E M. Analysis of terpenes in hemp (Cannabis sativa) by gas chromatography/mass spectrometry: Isomer identification analysis[M]//Comprehensive Analytical Chemistry. Elsevier, 2020, 90: 197-233.|[6]Yang M, et al. Determination and pharmacokinetic study of guaiol in rat plasma by gas chromatography–mass spectrometry with selected ion monitoring[J]. Journal of Chromatography B, 2018, 1085: 30-35.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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