AMP-PCP

• Description :

  AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/amp-pcp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2

• Molecular Formula :

  C11H18N5O12P3

• Molecular Weight :

  505.21

• References & Citations :

  [1]Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90

• CAS Number :

  [3469-78-1]