AMP-579

• UNSPSC Description:

  AMP-579 is an adenosine receptor agonist that primarily targets adenosine A1 and A2A receptors (with Ki values of 1.7 and 4.5 nM for the A1 receptor in rat brain and adipocytes, and a Ki value of 56 nM for the A2A receptor in rat brain). AMP-579 inhibits lipolysis, restores insulin-dependent glucose transport, and reduces heart rate through the activation of A1 receptors, while it induces vasodilation, particularly in coronary arteries, through the activation of A2A receptors (with an IC50 of 0.3 μM in porcine coronary arterial rings). AMP 579 shows potential for application in cardioprotection and the treatment of acute myocardial infarction[1].

• Target Antigen:

  Adenosine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/amp-579.html

• Smiles:

  O[C@H]1[C@@H](C[C@@H]([C@H]1O)C(NCC)=O)N2C3=NC=NC(N[C@H](CC)CC4=C(C=CS4)Cl)=C3C=C2

• Molecular Weight:

  478.01

• References & Citations:

  [1]Merkel L, et al. Pharmacological characterization of AMP 579, a novel adenosine A1/A2 receptor agonist and cardioprotective[J]. Drug development research, 1998, 45(1): 30-43.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  213453-89-5